This post is about the ENTSSO failure after having installed Visual Studio 2010 in your BizTalk environment.
The problem
After having installed Visual Studio 2010 on my 64-bit Windows 2008 server Enterprise Single Signed on stopped working. The event log tells us to call “regasm SSOSQL.dll” – which is very nice. Only it doesn’t work on 64-bit operating systems.

Solution
You need to explicitly call the 64-bit regasm tool from this location: “C:\Windows\Microsoft.NET\Framework64\v2.0.50727\regasm.exe”. The event log entry also doesn’t tell us where the SSOSQL.dll is located. Well, here it is: “C:\Program Files\Common Files\Enterprise Single Sign-On\SSOSQL.dll”.
The command to execute
With brackets and everything.
“C:\Windows\Microsoft.NET\Framework64\v2.0.50727\regasm.exe" "C:\Program Files\Common Files\Enterprise Single Sign-On\SSOSQL.dll"
Reboot and you should be on your merry way!